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Principal Scientist, Generative Deep Learning

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    Johnson & Johnson
    Company
    jnj.com

Job Details

Role: Principal Scientist, Generative Deep Learning

Location: Spring House, PA
Pay: 113,000−113,000 - 195,500 per year
Job Type: Full-time
Shift and Schedule: Holidays

About Johnson & Johnson Innovative Medicine

Company Overview:
Johnson & Johnson Innovative Medicine is committed to preventing, treating, and curing complex diseases. By leveraging expertise in Innovative Medicine and MedTech, the company strives to deliver breakthroughs in healthcare that are smarter, less invasive, and more personalized.

Diversity, Equity, and Inclusion:
Johnson & Johnson has a longstanding commitment to diversity, equity, and inclusion (DEI). Rooted in their Credo, they value a culture of belonging where all perspectives, abilities, and experiences are recognized. This commitment fuels their pursuit to solve the world’s most pressing healthcare challenges.

What You Will Do

As a Principal Scientist in Generative Deep Learning, you will play a critical role in driving molecular design and simulation initiatives that accelerate the discovery and development of protein-based therapeutics. You will collaborate extensively with interdisciplinary teams to apply deep learning methodologies in the design of therapeutic molecules for various clinical indications.

Key Responsibilities:

  • Model Development: Lead the development and refinement of generative models, such as RFDiffusion, ProteinMPNN, and EvoDiff, to enhance protein design capabilities.
  • AI Integration: Implement new structure-based protein design methods using the latest advancements in AI, including diffusion, Graph Neural Networks (GNNs), and Variational Autoencoders (VAEs).
  • Optimization: Integrate Multi-Property Optimization techniques into generative methods to improve molecule efficacy and specificity.
  • Contrastive Learning: Employ contrastive learning techniques to improve model adaptability and performance in differentiating functional protein structures.
  • Collaboration: Work closely with multi-functional teams to translate complex scientific challenges into actionable strategies and align AI tools with scientific goals.
  • Innovation: Maintain up-to-date knowledge of AI/ML trends, particularly in generative and discriminative modeling techniques, and evaluate their impact on research and development.
  • External Partnerships: Collaborate with external innovation partners on pioneering developments in generative protein design.

Qualifications

Required:

  • PhD with 2+ years of experience in Computer Science, Data Science, Computational Biology, Bioinformatics, or a related field with a strong emphasis on machine learning.
  • Expertise in developing and applying generative AI models, including deep learning architectures such as diffusion, VAEs, contrastive learning, and GNNs.
  • Proficient in scientific programming and software development, particularly in Python or C++, and deep learning frameworks such as TensorFlow or PyTorch.
  • Outstanding communication and leadership skills with the ability to lead innovative projects and motivate teams towards groundbreaking solutions.

Preferred:

  • Experience with high-performance computing and cloud-based compute solutions such as AWS.
  • Application of ML methods to computational protein design or modeling.
  • Familiarity with large datasets, data analysis workflows, and querying languages such as SQL.
  • Experience with ML packages for protein modeling and design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, EvoDiff, etc.
  • Desire for continuous learning and ability to identify, evaluate, and deploy emerging algorithms, models, and ML architectures.

Benefits

Comprehensive Benefits Include:

  • Health Insurance: Medical, dental, vision.
  • Life Insurance: Coverage for employees and dependents.
  • Disability Insurance: Short-term and long-term.
  • Retirement Plans: Participation in the Company’s pension plan and 401(k) savings plan.
  • Paid Time Off: Vacation (up to 120 hours/year), sick time (up to 40 hours/year), holiday pay (up to 13 days/year), personal and family time (up to 40 hours/year).

Additional Information

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more details on benefits, please visit Johnson & Johnson Employee Benefits.